Kairegene
Project Overview
About
Ageing increases the risk of many chronic diseases, but experimental cell-reprogramming techniques can erase cell identity if treatment goes too far. Kairegene is developing a self-regulating gene circuit delivered through short-lived messenger RNA. Molecular signals help estimate each cell’s biological age, allowing the circuit to adjust its dose of rejuvenating factors and switch itself off if identity loss begins. This responsive approach could make cellular rejuvenation safer and more consistent, supporting future treatments that extend healthy life and improving the control of other gene and cell therapies.
Team
Sofia Miron Barroso
Sofía Mirón Barroso is a postdoctoral researcher in David Sinclair’s laboratory at Harvard Medical School, where she studies aging and cellular rejuvenation. She holds a BSc in Biomedical Sciences, a Master’s degree in Nanomedicine, and a PhD from Imperial College London, where she developed RNA delivery systems for cancer therapeutics. Her research experience spans genomics at Stanford University, cellular senescence at the University of Cambridge, and RNA nanotechnology at Sixfold Biosciences, a biotech startup. She led the Excellerator 2023, a global event at Global Biotech Revolution. Sofía is passionate about translating advances in biology into technologies that improve human health.